His work centers on managing his family's conglomerate, the Santo Domingo Group. He is the chairman of Grupo Empresarial Bavaria S.A., a privately owned subsidiary of SABMiller, of which he is vice-chairman for Latin America. His partner is his maternal cousin, Carlos Alejandro Pérez Dávila, a former Goldman Sachs investment banker who helps him manage the family portfolio. Along with said cousin, he is also the managing Director of the New York-based Quadrant Capital Advisors, Inc. In 2009, Santo Domingo was elected to the Board of Trustees on the Metropolitan Museum of Art.

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